Antioksydanter og cellegiftbehandling

[mosto1365380741]

Hei!

Jeg har fra forskjellige hold fått høre at inntak av antioksydanter når en går på cellegiftbehandling kan medføre at noe av effekten fra cellegiften avtar.

Hvor kommer dette fra, og kan det medføre noen sannhet?

Har andre noen kommentarer til dette?

Mosto

[Molekylær]

Hei,

Du kan jo se om du finner dette interessant.

"In the September 1999 issue of The Journal of Oncology an article appeared in which the authors discuss possible theoretical negative interactions of cancer chemotherapy drugs and concurrent use of antioxidants.21 The experimental evidence for such a hypothesis is lacking and actually, in the majority of cases, shows the opposite.22"

Concern about Concurrent Use of Vitamin C and Chemotherapy

The Mayo studies of Creagan and Moertel, which rebutted Pauling’s and Cameron’s notorious findings, have closed the issue on vitamin C and cancer in the minds of many oncologists and allopathic physicians.12,13 However, Pauling pointed out serious design and interpretive flaws of these studies in a rebuttal paper which he was unable to get published. Clearly, the case is not closed. Clinical data demonstrate that ascorbic acid potentiates chemotherapy effects.14-17 However, there are still theoretical concerns from conventional oncology questioning the use of antioxidants, such as vitamin C, concurrently with chemotherapy. The majority of clinical evidence indicates the usefulness of antioxidants, like vitamin C, concurrently with most types of chemotherapy.18,19 In a recent review paper in The Journal of American Nutraceutical Association, Block and Evans reviewed all English articles listed in Index Medicus between the years 1990-2000 related to antioxidant and interactions with anticancer drugs or radiation and concluded that there is a rational basis for the continued use of antioxidant agents as a therapeutic adjunct in cancer therapy.20

The theoretical concern of antioxidant use concurrently during chemotherapy lies in the knowledge that many current clinical oncology drugs induce cellular toxicity and death through mechanisms of intracellular free radical generation, and it is thought that antioxidants may block this action. In the September 1999 issue of The Journal of Oncology an article appeared in which the authors discuss possible theoretical negative interactions of cancer chemotherapy drugs and concurrent use of antioxidants.21 The experimental evidence for such a hypothesis is lacking and actually, in the majority of cases, shows the opposite.22 There are only three presently known examples in which any agent classifiable as an antioxidant has been shown to decrease the effectiveness of radiation or chemotherapy in vivo, none of which applies to vitamin C.23 Vitamin C has been shown in both animal and human studies either to increase the efficacy and/or decrease the toxicity of the following chemotherapeutic agents: alkylating agents (cyclophosphamide, ifosfamide, busulphan, melphan), antibiotic type agents (doxorubicin [adriamycin], bleomyocin, epirubicin, daunorubicin), anti-metabolites (5-Fluorouracil, methotrexate), platinum compounds (cisplatin), radiotherapy, hormone therapies (tamoxefin) and plant alkaloids (etoposide, vincristine, paclitaxel).24 For further review, the reader is referred to the study by Lamson and Brignall, Alternative Medicine Review, April 2000.23

Vitamin C has been extensively tested in vitro and in vivo for its ability to prevent the adverse effects of, decrease resistance to, and increase the effects of chemotherapeutic agents.25 Combined administration of vitamin C (1g/kg) and vitamin K given prior to chemotherapy increased survival and the effect of several chemotherapeutic agents in a murine ascitic liver tumour model.26 The vitamin combination did not increase the toxicity of these agents to healthy tissue. Splenic and thymic weights of the vitamin-treated animals were higher than those receiving cytotoxic treatment alone, suggesting an immune-stimulating action of the vitamins. As well as being safe to use concurrently with chemotherapeutic agents, vitamin C has also been shown safe to be used concurrently with radiation.27 Vitamin C has been shown to have a radioprotective effect on normal cells while concurrently having a radiosensitizing effect on malignant ones.28,29

Abraham Hoffer, who has seen over 970 patients suffering from cancer in the last 20 years, has concluded that the optimum treatment for cancer today is a combination of xenobiotic and orthomolecular therapy and that the treatment must be started as soon as possible. Hoffer’s view is that orthomolecular treatment improves the quality of life, decreases side effects and is palatable. Furthermore, he states, There can be no logical reason today why most of the research funds should go only toward the examination of more chemotherapy and more ways of giving radiation. There must be a major expansion into the use of orthomolecular therapy to sort out the variables and to determine how to improve the therapeutic outcome of treatment.

For ytterligere informasjon og kildehenvisninger:

http://www.positivehealth.com/permit/Articles/Cancer/calvino71.htm

[Gjest Stig Bruset, Allmenpraktiserende Lege]

Antioksydanter er fellesbetegnelsen på en gruppe stoffer som inaktiverer reaktive surstoffmolekyler, såkalte frie radikaler. Disse potensielt skadelige molekylene er en del av sykdomsmekanismen bak kreft og andre degenerative sykdommer. De mest kjente er vitamin A,C,E og mineralene selen og sink. Matvarer som frukt og grønt inneholder hundrevis av ulike antioksidanter. Det er enighet om at antioksydanter i mat beskytter mot flere typer sykdommer inkludert kreft og hjerte- og karsykdom. Når det gjelder antioksydanter under pågående behandling er meningene delte. Professor Kedar Prasad fra universitetet i Colorado har forsket i mange år på antioksydanter og hevder at disse næringsstoffene ikke bare påvirker frie radikaler, men også immunsystemet og cellemodningen. Under et foredrag på en internasjonal konferanse i Oslo sommeren 2004 hevdet han at bruk av antioksydanter faktisk bedrer effekten av cellegift. Hans resept er:

Vitamin C 8 gram dgl

Vitamin E 800 IE dgl

Betakaroten (naturlig) 60 mg dgl

Vi mangler fortsatt gode studier på mennesker, så noen pasienter foretrekker en mellomting og skipper antioksydantene noen dager mens de får cellegiftbehandlingen.