Riboflavin og migrene referanse

[En_Mamma]

Her er referanse til studiet om riboflavin og migrene jeg spurte om for noen dager siden:

Schoenen J; Jacquy J; Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998 Feb;50(2):466-70.

Abstract:

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p = 0.002) and the number-needed-to-treat for effectiveness was 2.3. Three minor adverse events occurred, two in the riboflavin group (diarrhea and polyuria) and one in the placebo group (abdominal cramps). None was serious. Because of its high efficacy, excellent tolerability, and low cost, riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug.

Jeg var innom helsekostbutikken og apoteket idag men ser at det blir veldig dyrt å spise så mange vitamintabeletter som dette. Noen tips?

mvh,

[Gjest Stig Bruset, Allmenpraktiserende Lege]

Kjære En_Mamma,

Flott at du fant frem referansen - takk! Norsk Medisinaldepot skal føre riboflavin i 50 og 500 mg styrke, men da må de bestilles av lege på et skjema som heter "Registreringsfritak". Alle leger kan gjøre dette og du får vitaminene på ditt nærmeste apotek.